{"id":1876,"date":"2022-07-29T11:59:15","date_gmt":"2022-07-29T11:59:15","guid":{"rendered":"http:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/?page_id=1876"},"modified":"2023-03-11T21:27:48","modified_gmt":"2023-03-11T21:27:48","slug":"ht3-l3-alphafold-db-accessing-a-wealth-of-predicted-protein-structure-data","status":"publish","type":"page","link":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/ht3-l3-alphafold-db-accessing-a-wealth-of-predicted-protein-structure-data\/","title":{"rendered":"HT3 L3: AlphaFold DB \u2013 Accessing a wealth of predicted protein structure data"},"content":{"rendered":"<p><strong>HT3: Databases<img loading=\"lazy\" decoding=\"async\" class=\"wp-image-1908 alignright\" src=\"http:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-content\/uploads\/2022\/07\/armstrong-300x300.jpg\" alt=\"\" width=\"172\" height=\"172\" srcset=\"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-content\/uploads\/2022\/07\/armstrong-300x300.jpg 300w, https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-content\/uploads\/2022\/07\/armstrong-150x150.jpg 150w, https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-content\/uploads\/2022\/07\/armstrong-400x400.jpg 400w, https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-content\/uploads\/2022\/07\/armstrong-100x100.jpg 100w, https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-content\/uploads\/2022\/07\/armstrong.jpg 510w\" sizes=\"auto, (max-width: 172px) 100vw, 172px\" \/><\/strong><\/p>\n<h4>L3 (Lecture): AlphaFold DB \u2013 Accessing a wealth of predicted protein structure data<\/h4>\n<p>&nbsp;<\/p>\n<p><strong>David Armstrong<\/strong><br \/>\nProtein Data Bank in Europe (PDBe)<br \/>\nEuropean Bioinformatics Institute (EMBL-EBI)<br \/>\nE-mail: davida@ebi.ac.uk<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Predicting the 3D structure of proteins is one of the fundamental grand challenges in biology. By solving this challenge, we can dramatically deepen our understanding of human health, disease, and our environment, especially within areas like drug design and sustainability.<\/span><\/p>\n<p style=\"text-align: justify;\">\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">AlphaFold, the state-of-the-art AI system developed by DeepMind, is able to computationally predict protein structures with unprecedented accuracy and speed. The AlphaFold Protein Structure Database (AlphaFold DB), a collaboration between DeepMind and EMBL-EBI, enables free and open access to over 200 million protein structure predictions by AlphaFold. Included are nearly all cataloged proteins known to science \u2013 with the potential to increase humanity\u2019s understanding of biology by orders of magnitude.<\/span><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">Explore stories of AlphaFold\u2019s impact: <a href=\"http:\/\/unfolded.deepmind.com\/\">unfolded.deepmind.com\/<\/a><\/span><\/p>\n<p style=\"text-align: justify;\">&nbsp;<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-weight: 400;\">This talk will cover the background of AlphaFold DB, how to access the predicted structures, and how to interpret the data. Using some specific case studies, the talk will highlight how we can use this data to generate new hypotheses for testing to accelerate the progress of scientific research.<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>HT3: Databases L3 (Lecture): AlphaFold DB \u2013 Accessing a wealth of predicted protein structure data &nbsp; David Armstrong Protein Data Bank in Europe (PDBe) European Bioinformatics Institute (EMBL-EBI) E-mail: davida@ebi.ac.uk Predicting the 3D structure of proteins is one of the fundamental grand challenges in biology. By solving this challenge, we can dramatically deepen our understanding [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-1876","page","type-page","status-publish","hentry"],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/pages\/1876","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/comments?post=1876"}],"version-history":[{"count":2,"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/pages\/1876\/revisions"}],"predecessor-version":[{"id":2461,"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/pages\/1876\/revisions\/2461"}],"wp:attachment":[{"href":"https:\/\/hrvatska-udruga-kristalografa.hr\/htcc5\/wp-json\/wp\/v2\/media?parent=1876"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}